The march of the machines

Parts of human bodies are becoming machines and machines are becoming smart, like humans. And we are getting closer to understanding that ultimate human machine - the brain - by creating a copy of it on computers. 2013 saw dramatic strides in this mind-boggling adventure, but we're still not fully there. Here's a quick look at that and other advancements made this year.

Soft robotics

Forget about those clunky Star Wars-type robots. On the horizon are "soft robots", machines that are made of soft, humanlike materials. And it's not just that they look and behave more like humans. "When our hand wraps around a coffee mug, sensors in the hand inform the brain about the mug's shape, weight, temperature, texture, and the brain informs the muscles what to do about them. That's what we are aiming for," Rolf Pfiefer of the University of Zurich told TOI. His lab has developed the 4-ft tall and cute Roboy, unveiled this March, which has synthetic muscles, tendons and bones. It can walk and even ride a small bicycle. But the best news is this — the Roboy design will be put in the public domain once finalized. Just download and use a 3-D printer to make one for yourself.

Artificial limbs that can feel

In 2012, Zac Vawter walked up 103 floors of Chicago's Willis Tower wearing a mind-controlled bionic leg. But that was only half the battle won because the leg didn't tell the brain what it was feeling. The much vaunted "brain-machine interface" (BMI) was still a one-way street. That changed in 2013.

After Igor Spetic of Ohio lost his hand in an industrial accident, Dustin Tyler of Case Western Reserve University made an artificial hand and connected its wiring to nerve nodes on Spetic's upper arm. Spetic now has a sense of touch through 20 sensors in the prosthesis while his brain is able to control the hand's movements. In an experiment, Spetic was able to pluck the stems of cherries, taking care not to crush the fruit - an ability provided by the sensors.

Others like neuroscientist Miguel Nicolelis of Duke University have implanted tiny electrodes in monkeys' brains so that they can simultaneously move both their artificial arms to carry out given tasks. Nicolelis imaged the brain's cells firing up in tandem with the activity - a glimpse of living brain-machine interaction.

Deep learning

Remember Google's neural network last year that could recognize YouTube cats? Its developer Andrew Ng of Stanford's Artificial Intelligence Lab has created another, more than six times bigger.

Artificial neural networks are virtual models of biological brains. They show signs of deep learning or what Boston University's Stephen Grossberg, a pioneer in the field, calls autonomous intelligence — developing intelligence by interacting with the world.

Deep learning was utilized in several tasks by major players including Microsoft and Facebook, apart from Google. Microsoft used it to translate spoken English into spoken Chinese while Facebook hired top experts in the field to develop more killer apps. "It's both a software and a hardware problem together; the way you scale these networks requires very deep integration of the two," explained Srinivas Narayanan of Facebook to the MIT Technology Review.
Are we on the threshold of a scary sentient machine revolution? Not quite. Remember, the human brain has some 100 trillion connections, machines are struggling at 11 billion.

Decoding the human brain

Humans are making a decisive bid to understand the last frontier — the human brain. Two mega projects were launched this year. The EU-backed Human Brain Project (HBP), aimed at creating a complete computer model of the brain, and the USbacked BRAIN Initiative to image and map all brain cells (neurons ) and their interconnected circuits. Both involve developing new technologies, and both will lead to finally understanding how the 450-gm human brain can do so much. Heidelberg University's physicist Karlheinz Meier, HBP co-coordinator, told TOI that one of the aims is to shift present computing systems, which are very energy and space-intensive, to neuromorphic (" brain-like") machines. "This project is not about developing artificial intelligence. It is about understanding, and then simulating the brain so that we can draw benefits for medicine, computing and of course neuroscience," he said.

Internet of things

The most-sold personal care gizmo by Amazon this holiday season was the Fitbit Wristband, a sleep, exercise and health tracker that straps onto one's wrist. Meanwhile, LG has announced a new line of smart appliances like ovens, vacuum cleaners, and washing machines that will be connected to you through a messaging app. While you work at office, these appliances will be doing their work, updating you, and ready to take instructions from you.

The Internet of Things has come into its own this year. Wearable smart devices, like fitness trackers, watches, glasses, belts etc are most common. Then there are car and driving-related aids - pollution detectors, efficiency analysers and so on. At a bigger level, there are smart traffic lights. And of course, driverless cars made great progress in 2013. The biggest splash was made by Google Chauffeur, a software installed in cars that takes over the car confidently on freeways but is still slightly unsure in residential neighborhoods. University of Parma's BRAiVE moves autonomously on a mixed traffic route open to public traffic.

So what's coming in the future? The key of intelligence will be found in the smart interplay between mind, body, and environment, Christian Freksa, professor of cognitive systems at the University of Bremen in Germany, told TOI. "Future systems will need to have 'social competence', that is, competence for co-operation with other, only partly predictable cognitive agents," he said.

Gene discovery offers clues to reverse balding

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Researchers from the University of Southern California found new genes that may offer ways to reverse baldness and receding hairline. Researchers from the University of Southern California found new genes that may offer ways to reverse baldness and receding hairline.
SummaryResearch focuses on how gene Wnt7b, without which hair is much shorter, activates hair growth.
Scientists have identified a complex network of genes that control the cycles of hair growth, a finding that may offer ways to reverse baldness and receding hairline.
Researchers from the University of Southern California have described some of the factors that determine when hair grows, when it stops growing and when it falls out.
Krzysztof Kobielak, Eve Kandyba and colleagues focused on stem cells located in hair follicles (hfSCs), which can regenerate hair follicles as well as skin.
These hfSCs are governed by the signalling pathways BMP and Wnt - which are groups of molecules that work together to
control cell functions, including the cycles of hair growth.
The research focuses on how the gene Wnt7b activates hair growth. Without Wnt7b, hair is much shorter, scientists said.
The research identified a complex network of genes – including the Wnt and BMP signalling pathways – controlling the cycles of hair growth.
Reduced BMP signalling and increased Wnt signalling activate hair growth. The inverse – increased BMP signalling and decreased Wnt signalling – keeps the hfSCs in a resting state, scientists said.
Further research clarified the workings of the BMP signalling pathway by examining the function of two key proteins, called Smad1 and Smad5.
These proteins transmit the signals necessary for regulating hair stem cells during new growth.
"Collectively, these new discoveries advance basic science and, more importantly, might translate into novel therapeutics for various human diseases," said Kobielak.
"Since BMP signalling has a key regulatory role in maintaining the stability of different types of adult stem cell populations, the implication for future therapies might be potentially much broader than baldness – and could include skin regeneration for burn patients and skin cancer," Kobielak said.
The findings were published in the journals Stem Cells and the Proceedings of the National Academy of Sciences (PNAS).

Indian scientists invent insulin pills for diabetics

Indian scientists invent insulin pills for diabetics
LONDON: In a big breakthrough, Indian scientists have done what medical science has been trying to achieve since 1930 - an insulin pill for diabetics.

Since insulin's crucial discovery nearly a century ago, countless diabetes patients have had to inject themselves with the life-saving medicine.

Now Indian scientists have reported a new development toward a long-sought insulin pill that could save millions the pain of daily shots.

Published in the American Chemical Society journal, the advance could someday not only eliminate the "ouch" factor but also get needle-wary — and weary — patients to take their medicine when they should.

For years, researchers have sought a way to transform delivery of this therapy from a shot to a pill, but it has been a challenge.

The body's digestive enzymes that are so good at breaking down food also break down insulin before it can get to work.

In addition, insulin doesn't get easily absorbed through the gut into the bloodstream.

To overcome these hurdles, Sanyog Jain from India's National Institute of Pharmaceutical Education and Research combined two approaches to shield insulin from the digestive enzymes and then get it into the blood.

They packaged insulin in tiny sacs made of lipids, or fats called liposomes, which are already used in some treatments. Then, they wrapped the liposomes in layers of protective molecules called polyelectrolytes.

To help these "layersomes" get absorbed into the bloodstream, they attached folic acid, a kind of vitamin B that has been shown to help transport liposomes across the intestinal wall into the blood.

In rats, the delivery system lowered blood glucose levels almost as much as injected insulin, though the effects of the "layersomes" lasted longer than that of injected insulin.

Diabetes inhibits the production or use of insulin, which is a hormone that helps blood glucose or blood sugar become absorbed into cells and give them energy.

Diabetes is one of India's biggest health challenges. By 2030, India's diabetes burden is expected to cross the 100 million mark, against 87 million estimated earlier.

Type 1 diabetes occurs when the body doesn't make enough insulin, and type 2 diabetes occurs when the body doesn't make or use insulin very well, causing glucose to remain in the blood, which can lead to serious problems.

Libby Dowling, care advisor at Diabetes UK, said "Oral insulin could make a big difference to the lives of people with diabetes. Children, elderly people and those with a phobia of needles would benefit particularly if and when insulin capsules become a safe and effective treatment for the condition. Although more research is needed, Diabetes UK would very much like to see insulin capsules one day become a reality."

She added, "Many people with Type 2 diabetes take diabetes tablets. They are not the same as insulin. As yet insulin cannot be taken in tablet form because it would be broken down in the stomach before it could work. Diabetes tablets work in different ways to lower blood glucose levels - for example by stimulating the pancreas to produce more insulin, or by helping the body to use the insulin that it does produce more effectively"

Big breakthrough in cure for blindness

Big breakthrough in cure for blindness
The breakthrough could lead to the production of artificial tissue grafts made from the variety of cells found in the human retina.
LONDON: In a major breakthrough, an inkjet printer in Britain can print eye cells which can be used to cure human blindness.

For the first time ever, researchers from UK have used inkjet printing technology to successfully print two types of cells from the retina of adult rats - ganglion cells and glial cells.

The breakthrough could lead to the production of artificial tissue grafts made from the variety of cells found in the human retina and may aid in the search to cure blindness.

In their study, the researchers used a piezoelectric inkjet printer device that ejected the cells through a sub-millimetre diameter nozzle when a specific electrical pulse was applied. They also used high speed video technology to record the printing process with high resolution and optimised their procedures accordingly.

"In order for a fluid to print well from an inkjet print head, its properties, such as viscosity and surface tension, need to conform to a fairly narrow range of values. Adding cells to the fluid complicates its properties significantly," Dr Wen-Kai Hsiao from the Inkjet Research Centre in Cambridge University said.

Professor Keith Martin and Dr Barbara Lorber from the John van Geest Centre for Brain Repair, University of Cambridge, said "The loss of nerve cells in the retina is a feature of many blinding eye diseases. The retina is an exquisitely organised structure where the precise arrangement of cells in relation to one another is critical for effective visual function".

"Our study has shown, for the first time, that cells derived from the mature central nervous system, the eye, can be printed using a piezoelectric inkjet printer. Although our results are preliminary and much more work is still required, the aim is to develop this technology for use in retinal repair in the future".

The finding could be a big boon for blind people across the world. India is home to the world's largest number of blind people. Of the 37 million people across the globe who are blind, over 15 million are from India.

Once printed, a number of tests were performed on each type of cell to see how many of the cells survived the process and how it affected their ability to survive and grow.

The cells derived from the retina of the rats were retinal ganglion cells, which transmit information from the eye to certain parts of the brain, and glial cells, which provide support and protection for neurons.

"We plan to extend this study to print other cells of the retina and to investigate if light-sensitive photoreceptors can be successfully printed using inkjet technology. In addition, we would like to further develop our printing process to be suitable for commercial, multi-nozzle print heads," Professor Martin concluded.

At the moment the results are preliminary and provide proof-of-principle that an inkjet printer can be used to print two types of cells from the retina of adult rats.

This is the first time the technology has been used successfully to print mature central nervous system cells and the results showed that printed cells remained healthy and retained their ability to survive and grow in culture.

The ability to arrange cells into highly defined patterns and structures has recently elevated the use of 3D printing in the biomedical sciences to create cell-based structures for use in regenerative medicine.

BLINDNESS IN INDIA

India is now home to the world's largest number of blind people.

Of the 37 million people across the globe who are blind, over 15 million are from India.

75% of these are cases of avoidable blindness.

India faces severe shortage of optometrists and donated eyes for the treatment of blindness.

While India needs 40,000 optometrists, it has only 8,000.

India needs 2.5 lakh donated eyes every year.

India's 109 eye banks manage to collect a maximum of just 25,000 eyes, 30% of which can't be used.

India has only 12,000 ophthalmologists.

153 million people in the country require reading glasses but do not have access to them.

India has just 20 optometry schools which produce just 1,000 optometrists annually as against the 17 million people being added to the population during the same period.

Of the 15 million blind people in India, three million, 26% of whom are children, suffer due to corneal disorders.

But only 10,000 corneal transplants are being done every year due to the shortage of donated eyes.

India's health ministry expects to reach its blindness elimination target of 0.3% by 2015, five years before the WHO deadline of 2020.

testing delivery with drones, CEO Bezos says



Amazon testing delivery with drones, CEO Bezos says
Bezos said the drones, unmanned vehicles that fly through the air, could deliver packages that weigh up to five pounds (2.3 kg).
WASHINGTON: Amazon CEO Jeff Bezos revealed Sunday that his company is looking to the future with plans to use "octocopter" mini-drones to fly small packages to consumers in just 30 minutes.

The US retail giant's ambitious project still requires additional safety testing and federal approval, butBezos estimated that Amazon "Prime Air" would be up and running within four to five years.

A demo video posted on the company's website showed the tiny robotic devices picking up packages in small yellow buckets from Amazon's fulfillment centers and then whizzing through the air to deliver the items to customers just 30 minutes after they made their purchase on Amazon.com.

"I know this looks like science fiction. It's not," Bezos told CBS television's "60 Minutes" program.

"We can do half-hour delivery... and we can carry objects, we think, up to five pounds (2.3 kilograms), which covers 86 percent of the items that we deliver."

The mini-drones are powered by electric motors and could cover areas within a 10-mile (16-kilometer) radius of fulfillment centers, thus covering a significant portion of the population in urban areas.

They operate autonomously and drop the items at the target locations thanks to GPS coordinates transmitted to them.

"It's very green, it's better than driving trucks around," said Bezos. Amazon said the octocopters would be "ready to enter commercial operations as soon as the necessary regulations are in place," noting that the Federal Aviation Administration was actively working on rules for unmanned aerial vehicles.

It projected a more optimistic timeline than Bezos himself for the project to be activated, saying the FAA's rules could be in place as early as 2015 and that Amazon Prime Air would be ready at that time.

Bezos hinted that part of the motivation behind the mini-drones was to make sure Amazon remains on the cutting edge of the retail industry.

"Companies have short life spans... And Amazon will be disrupted one day," he said.

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Brain gain: Secret of crows' intelligence decoded

Brain gain: Secret of crows' intelligence decoded
Behavioural biologists have even called crows "feathered primates" because the birds make and use tools, are able to remember large numbers of feeding sites, and plan their social behaviour according to what other members of their group do.
BERLIN: Crows are no bird-brains! Scientists have for the first time demonstrated how the brains of crows produce intelligent behaviour when the birds have to make strategic decisions.

Researchers have long suspected that corvids - the family of birds including ravens, crows and magpies - are highly intelligent.

Behavioural biologists have even called crows "feathered primates" because the birds make and use tools, are able to remember large numbers of feeding sites, and plan their social behaviour according to what other members of their group do.

This high level of intelligence might seem surprising because birds' brains are constructed in a fundamentally different way from those of mammals, including primates - which are usually used to investigate these behaviours.

Neurobiologists Lena Veit and Professor Andreas Nieder from Eberhard Karls University of Tubingen in Germany investigated the brain physiology of crows' intelligent behaviour.

They trained crows to carry out memory tests on a computer. The crows were shown an image and had to remember it. Shortly afterwards, they had to select one of two test images on a touchscreen with their beaks based on a switching behavioural rules.

One of the test images was identical to the first image, the other different. Sometimes the rule of the game was to select the same image, and sometimes it was to select the different one.

The crows were able to carry out both tasks and to switch between them as appropriate. That demonstrates a high level of concentration and mental flexibility which few animal species can manage - and which is an effort even for humans.

The crows were quickly able to carry out these tasks even when given new sets of images. The researchers observed neuronal activity in the nidopallium caudolaterale, a brain region associated with the highest levels of cognition in birds.

One group of nerve cells responded exclusively when the crows had to choose the same image - while another group of cells always responded when they were operating on the "different image" rule.

By observing this cell activity, the researchers were often able to predict which rule the crow was following even before it made its choice.

The study published in Nature Communications provides valuable insights into the parallel evolution of intelligent behaviour.

"Many functions are realised differently in birds because a long evolutionary history separates us from these direct descendants of the dinosaurs," said Lena Veit.

"This means that bird brains can show us an alternative solution out of how intelligent behaviour is produced with a different anatomy," Veit said.

Alzheimer's a late stage of diabetes: Study


LONDON: Scientists have found that Alzheimer's - a neurodegenerative disorder - may actually be a late stage of Type 2 diabetes.

The findings also suggest that losing weight and exercising may ward off Alzheimer's, at least in the very early stages, researchers said.

The extra insulin produced by those with Type 2 diabetes also gets into the brain, disrupting its chemistry, which can lead to the formation of toxic clumps of amyloid proteins that poison brain cells, researchers said.

"The discovery could explain why people who develop T2 diabetes often show sharp declines in cognitive function, with an estimated 70 per cent developing Alzheimer's - far more than in the rest of the population," said Ewan McNay at Albany University in New York.

"People who develop diabetes have to realise this is about more than controlling their weight or diet. It's also the first step on the road to cognitive decline," McNay said.

The increased risk of Alzheimer's disease in Type 2 diabetics has been known for a long time.

McNay's research aimed at discovering the mechanism by which T2 diabetes might cause Alzheimer's.

He fed rats on a high-fat diet to induce T2 diabetes and then carried out memory tests, showing that the animals' cognitive skills deteriorated rapidly as the disease progressed, 'The Sunday Times' reported.

An examination of their brains showed clumps of amyloid protein had formed, of the kind found in the brains of Alzheimer's patients.

McNay suggests that, in people with Type 2 diabetes, the body becomes resistant to insulin, a hormone that controls blood-sugar levels - so the body produces more of it.

However, some of that insulin also makes its way into the brain, where its levels are meant to be controlled by the same enzyme that breaks down amyloid.

"High levels of insulin swamp this enzyme so that it stops breaking down amyloid. The latter then accumulates until it forms toxic clumps that poison brain cells. It's the same amyloid build-up to blame in both diseases - T2 diabetics really do have low-level Alzheimer's," McNay said.

The research was presented at the Society for Neuroscience meeting in San Diego.