Time's up: Gene can predict what time of day you will die

Clock
Scientists have discovered a gene that predicts the time of day that you’ll die. 'Not the date, fortunately, but the time of day,' says one. File image Source: Supplied
SCIENTISTS have discovered a gene variation that affects the human body clock so profoundly that it even predicts the time of day when an individual is most likely to die.
Researchers hope the findings could eventually be used to determine when heart or stroke patients should take medication to make it most effective, or when hospital patients should be monitored most closely.
The US team discovered the gene variation by accident when they were investigating the development of Parkinson’s and Alzheimer’s disease.
They looked at the sleeping patterns of 1200 healthy 65-year-olds who were also given annual neurological and psychiatric assessments.
They found a single molecule near a gene called ‘Period 1’ that had as its base either adenine (A) or guanine (G).
Type A is more common by a ratio of six to four, so because people have two sets of chromosomes, an individual has a 36 per cent chance of having two As, a 16 per cent chance of having two Gs, and a 48 per cent chance of an A and a G.
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The findings, published in the Annals of Neurology, showed that those with a AA genotype tend naturally to wake up about an hour earlier than those with GG, and the AGs wake up almost exactly in the middle.
They also showed that those with the AA or AG genotype died just before 11am on average, but those with the GG genotype tended to die at just before 6pm.
The study’s lead author Andrew Lim, from the Department of Neurology at Beth Israel Deaconess Medical Center in Boston, Massachusetts, said: "The internal “biological clock” regulates many aspects of human biology and behaviour.
"It also influences the timing of acute medical events like stroke and heart attack."
Clifford Saper, chief of neurology at BIDMC, said: "So there is really a gene that predicts the time of day that you’ll die. Not the date, fortunately, but the time of day."

'Love hormone' keeps committed men away from other women


 
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Love hormones
The 'love hormone' oxytocin may encourage fidelity by prompting men in relationships to keep their distance from attractive women, a new study has found.
German researchers found that men in monogamous relationships who were given an oxytocinnasal spray stayed about four to six inches farther away from an attractive, woman they didn't know, compared with men in monogamous relationships who received a placebo.
The oxytocin spray had no effect on the distance that single men chose to keep between themselves and the attractive woman, MyHealthNewsDaily reported.
"The results suggest the hormone promotes fidelity in humans," said study researcher Dr Rene Hurle­mann, of the University of Bonn.
The findings agree with previous research conducted on prairie voles, which suggested the hormone plays a role in pair-bonding.
In humans, oxytocin has been found to promote bonding between parents and children, increase trust, and reduce conflict between couples.
Earlier this year, a study found that couples with high levels of oxytocin in the early stages of a relationship were more likely to be together six months later than couples with lower levels of the hormone.
However, until now, there has been no evidence that a dose of oxytocin given after a couple gets together contributes to the maintenance of the relationship, the researchers said.
The study involved 57 heterosexual males, about half of whom were in monogamous relationships.
After receiving either a dose of oxytocin or placebo, participants were introduced to a female experimenter who they later described as "attractive".
During the encounter, the experimenter moved towards or away from the men, and they were asked to indicate when she was at an "ideal distance" away, as well as when she moved to a distance that felt "slightly uncomfortable".
The effect of oxytocin on the attached men was the same regardless of whether the female experimenter maintained eye contact, or averted her gaze.
Oxytocin also had no effect on the men's attitude toward the female experimenter - whether men received the oxytocin or the placebo, they rated her as being equally attractive.
In a separate experiment, the researchers found oxytocin had no effect on the distance men kept between themselves and a male experimenter.
The study was published in The Journal of Neuroscience.

Clues to early human behaviour


 

JOHN NOBLE WILFORD
At a rock shelter on a coastal cliff in South Africa, scientists have found an abundance of advanced stone hunting tools with a tale to tell of the evolving mind of early modern humans at least 71,000 years ago.
The discovery, reported in the current issue of the journal Nature, lends weight to the hypothesis that not only did anatomically modern Homo sapiens emerge in Africa but also, to a previously unsuspected extent, their cognitive capacity for abstract and creative thought and the conception of increasingly complex technologies associated with modern human behaviour.
The report describes the stone tools as microliths, thin blades about only an inch long that could be affixed to wood or bone. These tipped projectiles were either arrows propelled by bows or, more likely, spears launched by atlatls, wooden extensions of the throwing arm that act as a lever, imparting greater speeds and distances to the weapon. This technology, the researchers said, may have been pivotal to the success of Homo sapiens as humans left Africa and entered Eurasia some 50,000 years ago, encountering Neanderthals who were limited to hand-thrown spears.
The new evidence appeared to answer some critics who have contended that previous findings of early modern human behaviour in Africa have been spotty and short-lived. The rock shelter excavations at Pinnacle Point, near Mossel Bay, east of Cape Town, show that this micro-blade technology continued over 11,000 years, until 60,000 years ago. The report says the technology was also “typically coupled to heat treatment” processes in shaping sharp and durable blades that persisted for nearly 100,000 years.
One of the authors, Curtis W. Marean, director of the research and a paleoanthropologist at the Institute of Human Origins at Arizona State University, said, “Every time we excavate a new site in coastal South Africa with advanced field techniques, we discover new and surprising results that push back in time the evidence for uniquely human behaviours.”
Prior investigations showed that this microlithic technology appeared briefly between 65,000 and 60,000 years ago and then seemed to vanish. Such thin blades had not been found in abundance until about 20,000 years ago.
Marean said in a telephone interview that while some archaeologists were still sceptical of a strong African role in modern human behaviour, there was diminishing support for the more Eurocentric “creative explosion” concept, born of bedazzlement over the cave art and fine tools of Upper Paleolithic Europe, which became widespread after the arrival of modern humans.
“Ninety per cent of scientists are comfortable that fully modern humans and human cognition developed in Africa,” Marean said. “Now they have moved on. The questions are, how much earlier than 71,000 years did these behaviours emerge?”
Like many other archaeologists, Marean and his team have concentrated their investigations in the caves and rock shelters overlooking the Indian Ocean. In a global ice age beginning 72,000 years ago, many Africans fled the continent’s arid interior, heading for the more benign southern shore. Access to seafood and more plentiful plant and animal resources may have increased populations and encouraged technological advances, Marean said.
Richard G. Klein, a paleoanthropologist at Stanford University who has favoured a more sudden and recent origin of modern behaviour, about 50,000 years ago, questioned the reliability of the dating method for the tools, noting that “there is another team that has already argued for a much longer” time period for the toolmaking culture.
The hypothesis of earlier African origins of modern human behaviour and cognition has been gaining strength over the past decade or two. Two archaeologists, Alison S. Brooks of George Washington University and Sally McBrearty of the University of Connecticut, led the charge with publications of their analysis of increasing evidence of African art and ornamentations expressing a modern cognitive capacity and symbolic thinking.
In a commentary accompanying the Nature report, McBrearty, who was not involved in the research, wrote that she believed that “modern cognitive capacity emerged at the same time as modern anatomy and that various aspects of human culture arose gradually” over the course of subsequent millenniums.