Mathematicians coming of age to become the most sought after professionals

In recent times, IBM Research has been using mathematics to investigate some uniquely Indian problems like low-cost traffic speed analysis and standardisation of addresses.
In recent times, IBM Research has been using mathematics to investigate some uniquely Indian problems like low-cost traffic speed analysis and standardisation of addresses.
Sequencing a person's genome is an expensive and complicated exercise, but the benefits can be enormous if done well and quickly. You could calculate the risk of getting major diseases, develop new drugs, or provide targeted therapies. But because of the cost and difficulty, routine gene-sequencing has not started in a big way in India. Strand Life Sciences, a Bangalore-based life sciences company, decided recently to test the waters with a pilot project. It has sequenced the genome of about 20 people, and hopes to start a commercial service soon.


Such a service would have been unthinkable even two years ago. To sequence a genome quickly, the DNA has to be chopped up into bits and the pieces sequenced separately. Assembling these pieces of information into a meaningful whole is difficult, and requires special resources and mathematical techniques.

Instrumentation technology has advanced rapidly in recent times, but some of the most dramatic improvements have been in mathematical techniques.

And these have resulted in a precipitous drop in the cost of gene sequencing, which is now set to make a high impact on our lives. "Genome data is very different from other data," says Ramesh Hariharan, chief technology officer, Strand Life Sciences. "But algorithms and special mathematical techniques to deal with it have improved rapidly in the last two years."

The Plus Factor

It is a quiet revolution happening away from public view, but it is going to transform technology and business. As mathematical techniques improve, many day-to-day problems are being solved mathematically, thereby helping companies and governments take better decisions and forecast trends more accurately. Some of it is led by big data analytics companies, but the trend is deeper and more widespread than big data. A data-rich world is infinitely interesting to applied mathematicians, as they look for beautiful patterns and striking correlations among the huge amounts of data being collected every day. Says Bernard Meyerson, vice-president, IBM Research: "The magic of mathematics is the only way to discover useful information from so much data."

In recent times, IBM Research has been using mathematics to investigate some uniquely Indian problems like low-cost traffic speed analysis and standardisation of addresses. Across the world, IBM employs arguably the largest pool of mathematicians in a private organisation. They look at the world in a distinctly mathematical way, breaking down conventional business problems into equations that can be solved by modern computers. IBM is representative of a larger trend in the technology world, as private companies use mathematics increasingly to solve a variety of problems from customer acquisition to predicting infant mortality.

In the last few years, IBM has invested $15 billion in companies with such capabilities. During this period, its engineers have applied this capability to a mindboggling variety of situations. They have used mathematics to predict failures in semiconductor plants, plan marketing campaigns, understand visitor behaviour on websites, manage public water supply, and spot infections in infants well before the symptoms manifest. Apart from core industrial areas, IBM also researches topics like astrophysics, genomics and climate change because its mathematicians have seen fascinating connections between natural phenomena and its core businesses.


New software to help beat paralysis


NEW DELHI: A unique approach adopted by AIIMS AIIMS neurologists is offering new hope to stroke patients. This 'mirror therapy' involves creating an illusion, using webcam and special software, where a patient's paralysed limb moves in tandem with a healthy one. Researchers say the therapy helps activate the brain cells and leads to a faster recovery.

This is how it works: The patient suffering from partial paralysis is asked to sit in front of a computer-assisted webcam. While the camera captures the motion of the unaffected hand/leg, a special software creates a mirror image of the same, creating an illusion that the affected limb is moving.

Ashu Bhasin, the lead researcher who experimented with the therapy on 20 stroke patients at AIIMS, says that when the patient sees the moving hand/leg on laptop screen as the affected limb, he tries to imitate the movement in real environment. "Intensive repetition of this exercise seems to improve the motor potential of the affected," she said.

The 'mirror therapy' was invented by Vilayanur S Ramachandran and co-workers, Bhasin added, to alleviate the phantom limb pain in amputees. "Originally, a mirror was used to create the illusion. But we used the webcam because it was more handy and safer to use with patients suffering from neurological condition," she said.

The study — published in the latest issue of Neurology India — states the treatment regime was administered for eight weeks for 60-90 minutes." It adds, "There was an increase in the activation of primary motor area post therapy explaining the 'restitution' concept of neural plasticity. A shift in part of the frontal cortex of the brain was also observed post-therapy suggesting that physiotherapy in the form of mental imagery promotes a focused activation of the injured brain, augmenting recovery."

Conventional therapy seeks to restore mobility and movement by concentrating directly on the paralysed half of body using physical exercises and stimulation to treat partial paralysis — one of the most common long-term consequences of stroke.

The functional and behavioural recovery still needs to be understood, experts say, to evolve a definite pattern to help health care professionals to deal with the load of stroke patients. "Stroke is second leading cause of mortality in developing countries. The estimated prevalence of stroke in Asian countries is about 250-300 per 100,000 with a death rate of 1.2%. But the post-stroke rehabilitation services are non-structured and have not been standardized yet," said a senior doctor.

Saliva gland test could diagnose Parkinson's disease


Saliva gland test could diagnose Parkinson's disease
WASHINGTON: Testing a portion of a person's salivary gland may help diagnose Parkinson's disease for the very first time, says a new research.

Parkinson's affects mainly people over 50 years who suffer symptoms such as slowness, which may impede efforts to walk or to stand up, stiffness of muscles (rigidity) and tremors.

"There is currently no diagnostic test for Parkinson's disease," says study author Charles Adler, neurologist with Mayo Clinic in Arizona, US.

"We have previously shown in autopsies of Parkinson's patients that the abnormal proteins associated with Parkinson's are consistently found in the submandibular saliva glands, found under the lower jaw," adds Adler.

"Making a diagnosis in living patients is a big step forward in our effort to understand and better treat patients," says Adler, according to a Mayo Clinic statement.

The study involved a group of people averaging 68 years who had Parkinson's for an average of 12 years. They had responded to Parkinson's medication and would not have known saliva gland disorders.

Biopsies were taken of two different saliva glands: the submandibular gland and the minor saliva glands in the lower lip.

The surgical team was led by Michael Hinni and David Lott, at the Mayo Clinic and the biopsied tissues were tested for evidence of the abnormal Parkinson's protein by study co-author Thomas Beach, with Banner Sun Health Research Institute.

"This procedure will provide a much more accurate diagnosis of Parkinson's disease than what is now available," Beach says.

"One of the greatest potential impacts of this finding is on clinical trials, as at the present time some patients entered into Parkinson's clinical trials do not necessarily have Parkinson's disease and this is a big impediment to testing new therapies," Beach says.

The abnormal Parkinson's protein was detected in nine of the 11 patients who had enough tissue to study. Although Parkinson's disease can't be cured, medications may markedly improve symptoms.

These findings will be presented at the American Academy of Neurology's annual meeting in San Diego in March.