Zebrafish stem cells could heal human retinas

Published: Friday, Feb 1, 2013, 16:18 IST 
Place: Toronto | Agency: IANS
Stem cells from zebrafish, the staple of genetic research, could regenerate damaged cones in retinas and restore eyesight to people. Rods and cones in the eyes are the most important photoreceptors. In humans, rods provide night vision, while cones offer a full-colour look at the world during the day.
It was not known, says University of Alberta researcher Ted Allison, whether stem cells could be instructed to only replace the cones in its retina. This could have important implications for human eyesight, the journal Public Library of Science ONE reports.
Almost all success in regenerating photoreceptor cells to date had been limited to rods, not cones. Most previous experiments were conducted on nocturnal rodents, animals that require good night vision and have far more rods than cones, according to an Alberta statement.
"This is the first time in an animal research model that stem cells have only repaired damaged cones," said Allison. "For people with damaged eyesight, repairing the cones is most important because it would restore day-time colour vision.
Researchers say this shows some hope for stem cell therapy that could regenerate damaged cones in people, especially in the cone-rich regions of the retina that provide daytime/colour vision. Allison says the next step for his team is to identify the particular gene in zebrafish that activates repair of damaged cones.

Bangalorean shows the way to store more on less


BANGALORE: Karthik V Raman, a 27-year-old researcher with IBM, Bangalore, and alumnus of Massachusetts Institute of Technology(MIT), along with his team, has engineered templates for molecular memory devices which could store data up to 1,000 terabytes per square inch. It's a good example of the convergence of computer electronics and molecular biology as has been envisaged for some time.

Once his technology hits the market in about ten years, it could mean a dramatic shrinkage in the size of portable storage devices. Over the years, from clunky floppy disks to pen drives, there have been huge improvements in storing data - smaller devices are able to keep large amounts of data. Entire movies are now being carted around in pen drives about the size of your little finger.

Currently, the maximum storage in portable devices is 700 gigabytes per square inch. "The current technology can go up to only 1 terabyte per square inch," Karthik said, adding that it could replace the current storage technology in tablets and portable music systems. You could perhaps store your entire archive of movies, songs, photographs and videos on just one device.

The research, which was his thesis for a doctoral degree at MIT between December 2010 and June 2011, has been patented by the Boston institution. The Bangalore lad, a student of the department of material science and engineering at MIT, shares the patent with research supervisor Jagadeesh S Moodera of the department of physics and Francis Bitter of the Magnet Lab, MIT.

Karthik worked on molecular spintronics for his thesis. This is a developing area where the spin of the electrons in molecules of organic material is used to store data. The molecules largely consist of flat sheets of carbon (which are attached to zinc atoms), according to MIT News.

These molecules were developed by chemists headed by Swadhin Mandal at the Indian Institute of Science Education and Research, Kolkata. Currently, molecular storage devices work best at about -20 degree celsius.

"More research & development needs to be done before it's commercially available. We need to solve som fabrication challenges before it becomes scalable but we now know how to go about it," said Karthik.

He added, "The main problem is funding. There's very less funding in the initial stages of research in India, however ground-breaking it may be," he said.

At present, there aren't many researchers in the world working to control single molecule and molecular scale to make memory devices from them. "I'm optimistic that many researchers will start contributing to this work and in another 10 years, the device will be commercially available," he said.

The idea

A magnetic molecule (which is one-thousandth times the thickness of a human hair) on a ferromagnetic surface can now store binary information (0 and 1) allowing a thousand-fold increase in storage capacity of current hard drives. The magnetic molecule can selectively filter electrons having a spin of one kind which is needed to read information.

South Korea Makes Billion-Dollar Bet on Fusion Power

A fusion power demonstration reactor to be built in the 2030s in collaboration with the DoE's Princeton Plasma Physics Lab, represents a step toward commercial use

fusion power, K-STAR nuclear fusion reactor, nuclear fustionThe K-STAR nuclear fusion reactor, in Daejeon, South Korea, will be succeeded by a larger, more ambitious project.Image: EPA/Corbis
From Nature magazine
South Korea has embarked on the development of a preliminary concept design for a fusion power demonstration reactor in collaboration with the US Department of Energy's Princeton Plasma Physics Laboratory (PPPL) in New Jersey.
The project is provisionally named K-DEMO (Korean Demonstration Fusion Power Plant), and its goal is to develop the design for a facility that could be completed in the 2030s in Daejeon, under the leadership of the country’s National Fusion Research Institute (NFRI).
South Korea is already developing the Korea Superconducting Tokamak Advanced Research (K-STAR) project and contributing to ITER, the €15-billion (US$20-billion) experimental reactor being built in Cadarache, France, under the auspices of an international collaboration. K-DEMO is intended to be the next step toward commercial reactors and would be the first plant to actually contribute power to an electric grid.
“It is a very smart strategy to take advantage of the experience gained in constructing ITER and to immediately proceed to construct a fusion power plant like K-DEMO,” says Stephen Dean, president of Fusion Power Associates, an advocacy group in Gaithersburg, Maryland.
K-DEMO will serve as prototype for the development of commercial fusion reactors. According to the PPPL, it will generate “some 1 billion watts of power for several weeks on end”, a much greater output than ITER's goal of producing 500 million watts for 500 seconds by the late 2020s.
Building up know-how
In early 2012, the South Korean Ministry of Education, Science and Technology announced that developing technologies to build K-DEMO would be a priority for the next 10 years, establishing the know-how to permit the construction of a commercial fusion power plant between 2022 and 2036. The government also announced that it planned to invest about 1 trillion won (US$941 million) in the project. About 300 billion won of that spending has already been funded, according to a source within the ministry. The government expects the project to employ nearly 2,400 people in the first phase, which will last throughout 2016.
Robert Goldston, who was the director of the PPPL when it helped with the initial design of K-STAR, believes that the K-DEMO project is feasible, considering South Korea's commitment to its previous project. "There was a financial crisis in Asia right in the middle of the K-STAR project, but the government and fusion scientists were steady and serious about getting the job done, despite lots of hardship," he says. "My sense is that the Korean team, at all levels, is very dedicated to a steady pace even in adversity — and there is always adversity in big projects."
Lee Gyung-Su, a research fellow at NFRI and a former chairman of the ITER Management Advisory Committee, says that Korea is desperately in need of the energy that fusion could provide. “Korea has a lack of energy resources,” he says. “The population density is high and the country consumes so much energy," Lee adds, "we have a different perspective on fusion energy compared to the United States.”
ITER has experienced repeated delays and cost increases, prompting some critics to question whether the project will ever be completed. "It is already obvious that future commercial-size machines will be too large and costly, and too expensive to operate, to generate competitive energy," says Thomas Cochran, a consultant for the Natural Resources Defense Council in Washington DC. He adds that he believes South Korea should spend its resources on technologies that have the potential to provide a nearer-term impact on carbon emissions and climate change.
Lee acknowledges the criticism, but says that most of ITER's issues were of a management, rather than a technical nature. “The schedules are now mostly fixed and sorted out,” he says. “And risks always exist when it comes to a new finding in science, and the investment on the research and development has been made based on the estimation of such risks.”
Moreover, Lee adds, “we are willing to take risks, and need to innovate to survive".
This article is reproduced with permission from the magazine Nature. The article wasfirst published on January 21, 2013.