New US brain wave: Unlocking the mind


WASHINGTON: The Obama administration is planning a decade-long scientific effort to examine the workings of the human brain and build a comprehensive map of its activity, seeking to do for the brain what the Human Genome Project did for genetics.

The project, which the administration has been looking to unveil as early as March, will include federal agencies, private foundations and teams of neuroscientists and nanoscientists in a concerted effort to advance the knowledge of the brain's billions of neurons and gain greater insights into perception, actions and, ultimately, consciousness . Scientists with the highest hopes for the project also see it as a way to develop the technology essential to understanding diseases like Alzheimer's and Parkinson's , as well as to find new therapies for a variety of mental illnesses. Moreover, the project holds the potential of paving the way for advances in artificial intelligence.

The project, which could ultimately cost billions of dollars, is expected to be part of the president's budget proposal next month. And, four scientists and representatives of research institutions said they had participated in planning for what is being called the Brain Activity Map project. The details are not final, and it is not clear how much federal money would be proposed or approved for the project in a time of fiscal constraint or how far the research would be able to get without federal financing. In his state of the union address, Obama cited brain research as an example of how the government should "invest in the best ideas" .

"Every dollar we invested to map the human genome returned $140 to our economy — every dollar," he said. "Today our scientists are mapping the human brain to unlock the answers to Alzheimer's . They're developing drugs to regenerate damaged organs , devising new materials to make batteries 10 times more powerful. Now is not the time to gut these job-creating investments in science and innovation."

The initiative, if successful, could provide a lift for the economy . "The Human Genome Project was on the order of about $300 million a year for a decade," said George M Church, a Harvard University molecular biologist who helped create that project . "If you look at the total spending in neuroscience and nanoscience that might be relative to this today, we are already spending more than that. We probably won't spend less money, but we will probably get a lot more bang for the buck." Scientists said they hoped that federal financing would be more than $300 million a year.

Brain implants could create sense of touch in artificial limbs


Brain implants could create sense of touch in artificial limbs
One of the main flaws of current human, brain-controlled prosthetics is that patients cannot sense the texture of what they touch
WASHINGTON: Rats can't usually see infrared light, but they have "touched" it after Duke University neurobiologists fitted the animals with an infrared detector wired to electrodes implanted in the part of the mammalian brain that processes information related to the sense of touch.

One of the main flaws of current human, brain-controlled prosthetics is that patients cannot sense the texture of what they touch, said Duke neurobiologist Miguel Nicolelis, who carried out the study with his team.

His goal is to give quadriplegics not only the ability to move their limbs again, but also to sense the texture of objects placed in their hands or experience the nuances of the terrain under their feet.

His lab studies how to connect brain cells with external electrodes for brain-machine interfaces and neural prosthetics in human patients and non-human primates, giving them the ability to control limbs, both real and virtual, using only their minds.

He and his team have shown that monkeys, without moving any part of their real bodies, could use their electrical brain activity to guide the virtual hands of an avatar to touch virtual objects and recognize their simulated textures.

His latest study showed that the rats' cortexes respond both to the simulated sense of touch created by the infrared light sensors and to whisker touch, as if the cortex is dividing itself evenly so that the brain cells process both types of information.

This plasticity of the brain counters the current "optogenetic" approach to brain stimulation, which suggests that a particular neuronal cell type should be stimulated to generate a desired neurological function. Instead, stimulating a broader range of cell types might help a cortical region adapt to new sensory sources, said Nicolelis, who is a professor of neurobiology, biomedical engineering and psychology and neuroscience at Duke University.

His team recently documented the firing patterns of nearly 2,000 individual, interconnected neurons in monkeys. Recording the electrical activity from thousands of neurons at once is important for improving the accuracy and performance of neuroprosthetic devices, he said.

This brain-machine interface work is all part of an international effort called the Walk Again Project to build a whole-body exoskeleton that could help paralyzed people regain motor and sensory abilities using brain activity to control the apparatus.

He and his collaborators expect to first use the exoskeleton in the opening ceremony of the FIFA Soccer World Cup in June 2014.

Nicolelis said infrared sensing might be built into such an exoskeleton so patients wearing the suit could have sensory information about where their limbs are and how objects feel when they touch them.

His latest study was recently published in Nature Communications.

Cern takes a break for next quantum leap


GENEVA: Seven months after its scientists made a landmark discovery that may explain the mysteries of mass, Europe's top physics lab will take a break from smashing invisible particles to recharge for the next leap into the unknown.
From Thursday, the cutting-edge facilities at the European Organization for Nuclear Research (Cern) will begin winding down, then go offline on Saturday for an 18-month upgrade.
A vast underground lab straddling the border between France and Switzerland, Cern's Large Hadron Collider (LHC) was the scene of an extraordinary discovery announced in July 2012.
Its scientists said they were 99.9% certain they had found the elusive Higgs Boson, an invisible particle without which, theorists say, humans and all the other joined-up atoms in the Universe would not exist.
The upgrade will boost the LHC's energy capacity, essential for Cern to confirm definitively that its boson is the Higgs, and allow it to probe new dimensions like supersymmetry and dark matter.
"The aim is to open the discovery domain," said Frederick Bordry, head of Cern's technology department.
"We have what we think is the Higgs, and now we have all the theories about supersymmetry and so on. We need to increase the energy to look at more physics. It's about going into terra incognita (unknown territory)."