Brain gets rid of toxins as we sleep



LONDON: It's a wake-up call for an estimated 150 million people who don't get enough sleep. Scientists say sleep is the mechanism through which the body flushes waste from thehuman brain.

The brain's method of waste removal — the glymphatic system — is highly active during sleep, clearing away toxins responsible for Alzheimer's disease and other neurological disorders, according to a study.

Researchers say the brain's cells reduce in size during sleep, allowing waste to be removed more effectively. "This study shows that the brain has different functional states when asleep and when awake," said Maiken Nedergaard of the University of Rochester Medical Centre. "In fact, the restorative nature of sleep appears to be the result of the active clearance of the by-products that accumulate during wakefulness."

By 2030, the number of adults suffering from sleeplessness is projected to be around 1.57 million, corresponding to over 260 million experiencing sleep problems. Sleep disorders at present affect 5-10 % of Indians.

The brain's process of clearing waste had long eluded scientists for it couldn't be observed in the living brain till the advent of new imaging technologies like two photon microscopy.

Peek into the mind


CHANDIGARH: In his 1998 media address, former US president Bill Clinton strongly denied allegations of having sexual relations with a female employee of the White House. On the face of it, it seemed Clinton had been falsely implicated, but recently, technology has helped analyze his emotions at the time of his address.

In the more than five-minute video, a billboard was superimposed, which added its own algorithmic software to evaluate Clinton's underlying feelings. It demonstrated Clinton's "strong internal conviction", "desire to convince" and "desperation to win the support of Americans," while addressing the media.

Such analyses has become possible with the help of an emotion detection system that can easily understand the meaning of intonations of voices and represent them. The software is being widely used by various global companies, especially BPOs and consultancy firms.

Many interesting offshoots of this emotion detection software have been developed in the form of various apps. Some companies at IT Park, Chandigarh, are also using the software. Nitin Moudgil, who runs a software development firm at IT Park, said, "My clients are based in France and Sweden. Of late, I have started using an emotion detector software. It is really smart and helps you get a fair idea about the mindset of your potential client. Besides video calls, it also helps in text chatting."

Working, future prospects

A billboard is superimposed on the video or audio clip, that adds its own algorithmic evaluation software to understand original feelings. The software is an emotion detection system that strikes correlations between voice intonations before presenting a conclusion.

The algorithms could rank the enthusiasm of candidates by evaluating his reading or way of speaking and also analyse whether he is an introvert or extrovert inquisitive or more practical.

They can also evaluate a person"s mood and suggest a playlist of songs. The algorithms can help computers understand what humans feel, a field known as "affective computing".

New techniques have been developed in computational voice analysis that help machines to identify with the help of writing.

Helps to detect 400 different moods:

There are emotion detection software that can help detect 400 different mood variations, from happiness to sadness, optimism to dejection and seriousness to casualness.

Research and development is on and efforts are being made to introduce emotional understanding into practically everything humans do; including face-to-face interactions, driving cars or playing games.

Steve Jobs showed signs of loneliness and fatigue in last interview:

In one of his last interviews, while Steve Jobs recollected old memories and talked about his feelings while the i-phone was developed, he was actually feeling lonely and fatigued. This was deduced by an emotion detection software. The nearly two-minute youtube video has gone viral across the world.

"I had this idea of being able to get rid of the keyboard, type on a multi-touch glass display and I asked our folks, could we come up with a multi-touch display that I could type on, I could rest my hands on and type on. It (i-phone) was amazing," said a smiling Jobs in the interview. However, the billboard superimposed over this video said Jobs was in the throes of various emotions at the time. There were "conflicts between urges and self-control, loneliness, fatigue, emotional frustration, sadness mixed with happiness, possibly nostalgia." It is said in a ticker run over Jobs"s head.

Tel-Aviv based start-up behind this software:

Research in the direction of evaluating voice intonations to understand underlying emotions and meanings, was started way back in 2011. However, the first success was made in 2012, when a Tel Aviv (Israel) based start-up offered a nascent technology to study consumers" emotions in real time. Their initial clients were call centres. Gradually, more companies jumped into the field. At present, many softwares and apps are available for this.

Emotional analytics engine:

Most of the emotion detection software have their own algorithms that work on an independent emotional analytics engine. From the parent company, license of these algorithms are given to third parties to develop apps and to make a new class of devices capable of detecting real emotions.

Gray area; intruding privacy:

Many voices have also been raised on various platforms against the emotions detecting software. Protesters say it is tantamount to intruding into the private life of people and companies should take prior permission from their clients before using the software on them.

Questions have also been raised on the accuracy of results and findings as it could end up making arbitrary and discriminatory decisions.

Bacteria-eating virus -NEXT virus eating super virus?


Bacteria-eating virus to replace antibiotics?



British scientists have identified a virus which "eats" the bacteria that causes the hospital superbug Clostridium difficile (C.diff), in a breakthrough that could have major implications for the fight against antibiotic resistance. The technique represents a viable alternative to antibiotics for the treatment of bacterial infection, using naturally occurring viruses called bacteriophages — "eaters of bacteria", or phages for short.

Researchers at the University of Leicester have isolated phages that specifically target C.diff, an infection of the gut that killed 1,646 in the UK last year. In lab tests the viruses were 90% effective against the most dangerous strains of the bug. The danger posed by growing resistance to antibiotics is one of the gravest health risks facing the world. Martha Clokie, who led the research, said that phages could have a major role to play in coming decades.

"The future impact of antibiotics is dwindling at a pace that no one anticipated, with more and more bacteria out-smarting and 'out-evolving' these miracle drugs. This has reenergized the search for new treatments," she said.

Unlike antibiotics, phages generally only infect one strain of bacteria. This could make them particularly effective as a treatment for C.diff infections, which become dangerous when antibiotic treatments interfere with the balance of "good" bacteria in the gut. They work by infecting bacteria cells, and replicating their DNA inside the cell. This leads to the cell bursting open and dying, with the new phages released from the dead cell and spreading to kill off other bacteria cells.