The march of the machines

Parts of human bodies are becoming machines and machines are becoming smart, like humans. And we are getting closer to understanding that ultimate human machine - the brain - by creating a copy of it on computers. 2013 saw dramatic strides in this mind-boggling adventure, but we're still not fully there. Here's a quick look at that and other advancements made this year.

Soft robotics

Forget about those clunky Star Wars-type robots. On the horizon are "soft robots", machines that are made of soft, humanlike materials. And it's not just that they look and behave more like humans. "When our hand wraps around a coffee mug, sensors in the hand inform the brain about the mug's shape, weight, temperature, texture, and the brain informs the muscles what to do about them. That's what we are aiming for," Rolf Pfiefer of the University of Zurich told TOI. His lab has developed the 4-ft tall and cute Roboy, unveiled this March, which has synthetic muscles, tendons and bones. It can walk and even ride a small bicycle. But the best news is this — the Roboy design will be put in the public domain once finalized. Just download and use a 3-D printer to make one for yourself.

Artificial limbs that can feel

In 2012, Zac Vawter walked up 103 floors of Chicago's Willis Tower wearing a mind-controlled bionic leg. But that was only half the battle won because the leg didn't tell the brain what it was feeling. The much vaunted "brain-machine interface" (BMI) was still a one-way street. That changed in 2013.

After Igor Spetic of Ohio lost his hand in an industrial accident, Dustin Tyler of Case Western Reserve University made an artificial hand and connected its wiring to nerve nodes on Spetic's upper arm. Spetic now has a sense of touch through 20 sensors in the prosthesis while his brain is able to control the hand's movements. In an experiment, Spetic was able to pluck the stems of cherries, taking care not to crush the fruit - an ability provided by the sensors.

Others like neuroscientist Miguel Nicolelis of Duke University have implanted tiny electrodes in monkeys' brains so that they can simultaneously move both their artificial arms to carry out given tasks. Nicolelis imaged the brain's cells firing up in tandem with the activity - a glimpse of living brain-machine interaction.

Deep learning

Remember Google's neural network last year that could recognize YouTube cats? Its developer Andrew Ng of Stanford's Artificial Intelligence Lab has created another, more than six times bigger.

Artificial neural networks are virtual models of biological brains. They show signs of deep learning or what Boston University's Stephen Grossberg, a pioneer in the field, calls autonomous intelligence — developing intelligence by interacting with the world.

Deep learning was utilized in several tasks by major players including Microsoft and Facebook, apart from Google. Microsoft used it to translate spoken English into spoken Chinese while Facebook hired top experts in the field to develop more killer apps. "It's both a software and a hardware problem together; the way you scale these networks requires very deep integration of the two," explained Srinivas Narayanan of Facebook to the MIT Technology Review.
Are we on the threshold of a scary sentient machine revolution? Not quite. Remember, the human brain has some 100 trillion connections, machines are struggling at 11 billion.

Decoding the human brain

Humans are making a decisive bid to understand the last frontier — the human brain. Two mega projects were launched this year. The EU-backed Human Brain Project (HBP), aimed at creating a complete computer model of the brain, and the USbacked BRAIN Initiative to image and map all brain cells (neurons ) and their interconnected circuits. Both involve developing new technologies, and both will lead to finally understanding how the 450-gm human brain can do so much. Heidelberg University's physicist Karlheinz Meier, HBP co-coordinator, told TOI that one of the aims is to shift present computing systems, which are very energy and space-intensive, to neuromorphic (" brain-like") machines. "This project is not about developing artificial intelligence. It is about understanding, and then simulating the brain so that we can draw benefits for medicine, computing and of course neuroscience," he said.

Internet of things

The most-sold personal care gizmo by Amazon this holiday season was the Fitbit Wristband, a sleep, exercise and health tracker that straps onto one's wrist. Meanwhile, LG has announced a new line of smart appliances like ovens, vacuum cleaners, and washing machines that will be connected to you through a messaging app. While you work at office, these appliances will be doing their work, updating you, and ready to take instructions from you.

The Internet of Things has come into its own this year. Wearable smart devices, like fitness trackers, watches, glasses, belts etc are most common. Then there are car and driving-related aids - pollution detectors, efficiency analysers and so on. At a bigger level, there are smart traffic lights. And of course, driverless cars made great progress in 2013. The biggest splash was made by Google Chauffeur, a software installed in cars that takes over the car confidently on freeways but is still slightly unsure in residential neighborhoods. University of Parma's BRAiVE moves autonomously on a mixed traffic route open to public traffic.

So what's coming in the future? The key of intelligence will be found in the smart interplay between mind, body, and environment, Christian Freksa, professor of cognitive systems at the University of Bremen in Germany, told TOI. "Future systems will need to have 'social competence', that is, competence for co-operation with other, only partly predictable cognitive agents," he said.

Gene discovery offers clues to reverse balding

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Researchers from the University of Southern California found new genes that may offer ways to reverse baldness and receding hairline. Researchers from the University of Southern California found new genes that may offer ways to reverse baldness and receding hairline.
SummaryResearch focuses on how gene Wnt7b, without which hair is much shorter, activates hair growth.
Scientists have identified a complex network of genes that control the cycles of hair growth, a finding that may offer ways to reverse baldness and receding hairline.
Researchers from the University of Southern California have described some of the factors that determine when hair grows, when it stops growing and when it falls out.
Krzysztof Kobielak, Eve Kandyba and colleagues focused on stem cells located in hair follicles (hfSCs), which can regenerate hair follicles as well as skin.
These hfSCs are governed by the signalling pathways BMP and Wnt - which are groups of molecules that work together to
control cell functions, including the cycles of hair growth.
The research focuses on how the gene Wnt7b activates hair growth. Without Wnt7b, hair is much shorter, scientists said.
The research identified a complex network of genes – including the Wnt and BMP signalling pathways – controlling the cycles of hair growth.
Reduced BMP signalling and increased Wnt signalling activate hair growth. The inverse – increased BMP signalling and decreased Wnt signalling – keeps the hfSCs in a resting state, scientists said.
Further research clarified the workings of the BMP signalling pathway by examining the function of two key proteins, called Smad1 and Smad5.
These proteins transmit the signals necessary for regulating hair stem cells during new growth.
"Collectively, these new discoveries advance basic science and, more importantly, might translate into novel therapeutics for various human diseases," said Kobielak.
"Since BMP signalling has a key regulatory role in maintaining the stability of different types of adult stem cell populations, the implication for future therapies might be potentially much broader than baldness – and could include skin regeneration for burn patients and skin cancer," Kobielak said.
The findings were published in the journals Stem Cells and the Proceedings of the National Academy of Sciences (PNAS).

Indian scientists invent insulin pills for diabetics

Indian scientists invent insulin pills for diabetics
LONDON: In a big breakthrough, Indian scientists have done what medical science has been trying to achieve since 1930 - an insulin pill for diabetics.

Since insulin's crucial discovery nearly a century ago, countless diabetes patients have had to inject themselves with the life-saving medicine.

Now Indian scientists have reported a new development toward a long-sought insulin pill that could save millions the pain of daily shots.

Published in the American Chemical Society journal, the advance could someday not only eliminate the "ouch" factor but also get needle-wary — and weary — patients to take their medicine when they should.

For years, researchers have sought a way to transform delivery of this therapy from a shot to a pill, but it has been a challenge.

The body's digestive enzymes that are so good at breaking down food also break down insulin before it can get to work.

In addition, insulin doesn't get easily absorbed through the gut into the bloodstream.

To overcome these hurdles, Sanyog Jain from India's National Institute of Pharmaceutical Education and Research combined two approaches to shield insulin from the digestive enzymes and then get it into the blood.

They packaged insulin in tiny sacs made of lipids, or fats called liposomes, which are already used in some treatments. Then, they wrapped the liposomes in layers of protective molecules called polyelectrolytes.

To help these "layersomes" get absorbed into the bloodstream, they attached folic acid, a kind of vitamin B that has been shown to help transport liposomes across the intestinal wall into the blood.

In rats, the delivery system lowered blood glucose levels almost as much as injected insulin, though the effects of the "layersomes" lasted longer than that of injected insulin.

Diabetes inhibits the production or use of insulin, which is a hormone that helps blood glucose or blood sugar become absorbed into cells and give them energy.

Diabetes is one of India's biggest health challenges. By 2030, India's diabetes burden is expected to cross the 100 million mark, against 87 million estimated earlier.

Type 1 diabetes occurs when the body doesn't make enough insulin, and type 2 diabetes occurs when the body doesn't make or use insulin very well, causing glucose to remain in the blood, which can lead to serious problems.

Libby Dowling, care advisor at Diabetes UK, said "Oral insulin could make a big difference to the lives of people with diabetes. Children, elderly people and those with a phobia of needles would benefit particularly if and when insulin capsules become a safe and effective treatment for the condition. Although more research is needed, Diabetes UK would very much like to see insulin capsules one day become a reality."

She added, "Many people with Type 2 diabetes take diabetes tablets. They are not the same as insulin. As yet insulin cannot be taken in tablet form because it would be broken down in the stomach before it could work. Diabetes tablets work in different ways to lower blood glucose levels - for example by stimulating the pancreas to produce more insulin, or by helping the body to use the insulin that it does produce more effectively"