Cause of mysterious food allergy discovered: It is genes

BY admin | July 14, 2014

Cause of mysterious food allergy has finally been discovered. Experts say it is genes that is to be blamed.

A new study claimed to have found the reason behind an inexplicable food allergy and claimed to have a new therapy that can cure it.

Eosinophillic esophagitis (EoE), a chronic inflammatory disorder of the esophagus which is prompted by allergic hypersensitivity to some foods and an over-accretion in the esophagus of white blood cells called eosinophils.


EoE is responsible for various gastrointestinal illness including reflux-like symptoms, vomiting, difficulty swallowing, tissue scarring, fibrosis, the formation of strictures and other medical problems.

Scientists at the Cincinnati Children’s Hospital Medical Center found that a molecular pathway explicit to epithelial tissue in the esophagus linking a gene called CAPN14, which becomes considerably up-regulated in the disease progression.

Researchers claimed that when the epithelial cells were exposed to Interleukin 13 (IL-13), an immune hormone and a prominent molecular activator of EoE, it led remarkable up-regulation of CAPN14.